Library
The Project Santa Fe Foundation Team is proud to share updates on our endeavors via Value-Based Care & Population Health Diagnostics Journal, publications, white papers, and press releases. Please browse our library and share with your colleagues as you see fit, at no cost to you. If you feel aligned with our thought leadership and would like to participate in our movement, we would be thrilled to hear from you. Please email us at info@cl2lab.org.
VBC Diagnostics Journal
Establishing a Global Repository for Generalizable AI in Healthcare
Jun 10, 2026
The Clinical Lab 2.0 (CL2.0) Lab-Initiated Care Model represents a transformative initiative designed to establish a global, publicly accessible repository of aggregated, deidentified laboratory data linked to patient outcomes. This model seeks to overcome limitations inherent in single-site datasets, fostering the development of generalizable, predictive artificial intelligence (AI) models that significantly enhance care optimization, diagnostic…
Beyond the Bench: Redefining the Medical Laboratory Professional as a Diagnostic Health Consultant
May 7, 2026
This manuscript examines the gaps in the educational curriculum for medical laboratory science programs and their consequential impact on population health. It emphasizes the need for better defining the roles and responsibilities of medical laboratorians, from technologists to pathologists. Additionally, it introduces the concept of a mid-level provider, the diagnostic health consultant, who can bridge…
Demonstrating the Value of Laboratory Medicine in Population Health and Value Based Care
Apr 13, 2026
The rapidly changing environment of healthcare is shifting towards value-based care and engaging patients as active participants in their wellness. This shift presents a unique opportunity to transform the role of laboratory diagnostic services to actively collaborate with providers, health systems, and patients to improve outcomes and reduce overall costs. The national focus addressing chronic…
Publications
The Role of the Clinical Laboratory in Diagnostic Stewardship and Population Health
Jan 3, 2025
Background: As healthcare identifies new opportunities to provide patient services and moves from volume to value payment models, the clinical laboratory is in an ideal position to serve as a catalyst for these changes. In 2017, the Project Santa Fe Foundation (PSFF) was founded to support the clinical laboratory’s role to promote the objectives of population…
Lab 2.0, Medicare 2030, AI – How they come together
Sep 11, 2024
The term value-based care is spoken of often, but what part do laboratories play in it and how can they be paid for it? What is Medicare 2030, and what does it mean for laboratories? How can AI be used to practice the medicine of tomorrow?
A Retrospective Multi-site Examination of Chronic Kidney Disease Using Longitudinal Laboratory Results and Metadata to Identify Clinical and Financial Risk
Apr 4, 2024
A retrospective, non-experimental, non-interventional study was conducted at 3 health care organizations to identify clinical gaps in care for patients with stage 3 or 4 chronic kidney disease (CKD), and financial opportunity from risk adjustment payment systems. Lack of evaluation for CKD in patients with diabetes was also assessed. Methods: Outpatient longitudinal laboratory results and patient…
White Papers
Following the Money: Passing the Baton
June 29, 2026
This session focused on one central issue: how diagnostics, specifically lab data, can generate revenue based on the value created rather than just reimbursement for the test performed. The panel argued that labs can do much more than return a result: they can identify risk earlier, improve care coordination, close care gaps, and help health…
Government Affairs in the Clinical Lab 2.0 Movement
April 29, 2026
Clinical Lab 2.0 represents a fundamental shift in how medical laboratories serve patients and the healthcare system. The Old Model (Lab 1.0): Laboratories run tests and report numbers. A passive, behind-the-scenes service where the lab functions as specimen processors. The New Model (Lab 2.0): Laboratories become active diagnostic partners in patient care, interpreting test results…
What We Walked Away With
April 8, 2026
We are all very aware that clinical laboratories and technology are rapidly evolving. From a Lab 1.0 model of confirming disease once symptoms appear to the Lab 2.0 approach of predicting risk earlier using data already generated in routine testing, we are moving the needle toward well-care and population health! At the Public Workshop, participants…
Press Releases
Dr. Mario Plebani Appointed Global Editor-in-Chief of Project Santa Fe Foundation’s Publication Division
Jul 27, 2026
SALT LAKE CITY, July 2026 — Project Santa Fe Foundation (PSFF) announces the appointment of Dr. Mario Plebani as Global Editor-in-Chief of its publication division, which will launch the Value-Based Care and Population Health Diagnostics Journal. This appointment marks a significant milestone in PSFF’s mission to transform laboratory medicine from reactive result-reporting to proactive, predictive…
Project Santa Fe Foundation Welcomes Vivica as Partner to Advance Value-Based Care in Clinical Diagnostics
Apr 21, 2026
Clinical Lab 2.0, an initiative of Project Santa Fe Foundation, the leading nonprofit advancing value-based care models across the U.S. healthcare system, announced a formal partnership with Life Data Lab, LLC, the developer of Vivica LabReports™, a proactive laboratory platform that enables clinical labs to surface actionable insights into potential patient care gaps* and support…
DMC Unveils ZetaStorm Platform at CL2.0 Public Workshop
Mar 24, 2026
Diagnostic Medicine Consortium Demonstrates ZetaStorm Platform Integrating Diagnostic Data, Real World Data (RWD), and Clinical Trial Forecasting Salt Lake City, UT — The Diagnostic Medicine Consortium (DMC)—a joint venture nonprofit of the Project Santa Fe Foundation and the Association for Pathology Informatics (API)—unveiled its emerging technology model at the Project Santa Fe Clinical Lab 2.0…