Demonstrating the value of the laboratory professional and longitudinal laboratory data is challenging and complex.  Healthcare quality and total cost of care can be impacted by a wide variety of interventions that may not necessarily reflect the work completed by the laboratory.  One clear measure of the laboratory’s value can be the identification of gaps in care when compared to national treatment guidelines, early identification of disease before it is documented in the medical record, and risk stratification of patients to identify sub-groups with the highest need for support.  Accruing quantitative metrics and outcomes that can be attributed to laboratory involvement requires rigorous project design, and teamwork among the multi-disciplinary members of the project team.  The CL2.0 demonstration projects that have reached completion are excellent examples of the value that can be demonstrated for the clinical laboratory.